FACULTY OF PHARMACY
Pharm D V-Year (Main Backlog) Examination, July 2018
Subject: Clinical Pharmacokinetics Pharmacotherapeutic Drug Monitoring
Time: 3 Hours Max.Marks: 70
Note: Answer all questions from Part A. Any Five questions from Part B.
PART A (10x2 20 Marks)
1 What is the role of pharmacist in clinical pharmaceutics?
2 What type of drugs should be monitored?
3 Why is creatinine clearance used in renal disease?
4 Write the TDM of digoxin.
5 Write the significance of population pharmacokinetics.
6 Write a note on indications for TDM.
7 Write a note on effect of hepatic disease on pharmacokinetics.
8 Name and contrast any two methods adjusting drug dose in renal disease.
9 Write any one method of dosage conversion from IV to oral dosing.
10 Define pharmacogenetics and write its applications.
PART B (50 Marks)
11 Describe the effect of genetic polymorphism in drug transport and drug targets.
12 Explain TDM of drugs used in cardiovascular and organ transplantations.
13 Explain the drug dosing in elderly, pediatrics and obese patients.
14 Explain the measurement of glomerular filtration rate and creatinine clearance.
15 Explain various pharmacokinetic drug drug interactions along with suitable
examples.
16 Write a note on protocols for TDM and explain how TDM will affect individualization
of drug dosage regime.
17 Explain briefly extracorporeal removal of drugs. 5
Write a note on dosage adjustment in renal disease. 5
18 Explain briefly Bayesian theory and analysis of population pharmacokinetic data.