FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutics) I-Semester (Main) Examination, February 2018
Subject: Modern Pharmaceutics
Time: 3 Hours Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 Discuss the different orders of reaction and their applications? 7
Discuss the production facilities and formulations of parenterals? 8
2 Discuss the ICH guidelines for calibration and validation of equipment with an
example? 8
Describe the validation of tableting process? 7
3 Discuss the sales forecasting and budget planning in pharmaceutical industries? 8
Describe the layout of buildings, services, equipment and their maintenance in
industries? 7
4 What is compaction profile? Explain the phases of compaction profile with a
suitable examples? 5
Define the term intrinsic solubility How to determine it's significance? 5
Explain the properties of granules effecting the compression behavior of tablets? 5
5 Discuss student t-test and it's applications? 5
Discuss the pharmacokinetic parameters for determination of bioavailability? 5
Describe the comparison of dissolution profiles of dosage forms using similarity
and difference factors? 5
6 Describe the influence of temperature on rate of reaction? 3
(b)Explain the methods for testing of drug excipient compatability studies? 6
Describe the preparation of SMEDDS and their evaluation tests? 6
7 Describe the preformulation of suspensions? 4
Explain the ANOVA test? 7
Describe the sterilization procedures for evaluation of parenterals? 4
8 Discuss the methods for improvement of aqueous solubilty of drugs? 8
Write Heckle equation and draw Heckle plots for porosity and explain them? 7