FACULTY OF PHARMACY
M. Pharmacy (Pharmacology) I-Semester (Main) Examination, February 2018
Subject: Pharmacological and Toxicological Screening Methods I
Time: 3 Hours Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 Describe in detail about regulations for laboratory animal care as per
CPCSEA guidelines.
Define Bioassay. Discuss the principle involved in bioasssay.
2 Define Parkinsonism. Enlist the models available to screen drugs for Parkinsonism
and explain any two methods.
3 Describe the preclinical screening procedures for the following:
Anti ulcer
Anti-asthmatics
4 Describe the screening methods for the evaluation of the following activities of a
compound
Antiarrythmics
Hepatoprotective drugs
5 Describe the screening methods used to evaluate the therapeutic activity of the
following:
Drugs for Alzheimer's disease
Antiepileptics
6 Define immunoassay. Outline principles of immunoassay and describe different
types of immunoassays.
7 List out the methods available to induce inflammation and describe the use of
acute and chronic model in the screening of anti-inflammatory agents.
8 What is diabetes? List out the methods available for induction of diabetes
experimentally. Discuss streptozotocin induced method for the screening of
antidiabetic agents.