FACULTY OF PHARMACY
M. Pharmacy (Pharmacology) II-Semester Main Examination,
August 2018
Subject Pharmacological and Toxicological Screening Methods-II
Time 3 Hours Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1. Write in detail on OECD guidelines for conducting toxicity studies. 15
2. Describe in detail the flow chart of Preclinical studies. 10
Explain the dermal toxicity studies. 5
3. Write about the importance Application of toxico kinetic's. 15 4. Write in detail about safety pharmacology. 8
Discuss in brief tier safety pharmacology studies 7
5. Discuss in detail the importance of ICH guidelines for toxicity studies. 15
6. Write a note on
The principles of regulatory toxicology. 7
Alternative to animal models in preclinical toxicology studies. 8
7. Write about the risk assessment in male reproductive toxicity. 8
Explain the single dose and repeat dose toxicity studies as per OECD
guidelines 7
8. Discuss in detail about IND studies 8
Write a note on determination of LD 50 as per OECD- 423 guidelines 7