FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) I-Semester (Supple.) Examination,
August 2018
Subject: Advanced Organic Chemistry I
Time: 3 Hours Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 Explain the structure and stability of carbocations and carbanions.
Discuss SN1 and SN2 reactions with mechanism and stereochemistry.
2 What is retrosynthesis? Discuss C C disconnections in alcohols and
carbonyls compounds having and 5 difunctionalized
groups.
Explain the terms Synthon Synthetic agent FGI FGA with
suitable examples.
3 Discuss the mechanism and synthetic applications of any three of the following
named reactions.
Ullmann coupling reaction
Sandmeyer reaction
Baeyer villiger oxidation
Michael addition
Doebner Miller reaction
4 Explain the role of protecting groups in organic synthesis.
Explain how hydroxyl group, diols and carbonyl groups are protected
during the reactions.
Explain mechanism and applications of
Aluminium isopropoxide
Diazomethane
5 Mention the heterocycle present and also outline the steps involved in the
synthesis of any three of the following drugs:
Ketoconazole
Celecoxib
(iii)Chlorpromazine
(iv)Sulfamerazine
Alprozolam
Explain C C and C N rearrangement reactions. Give one example for
each.
6 Write notes on any thee of the following:
Hoffman and Saytzeff's rule
Ozonolysis
Traube purine synthesis
Combes quinoline synthesis
BOP reagent
..2
Library
G.Pulla Reddy College of Pharmacy
HyderabadOU 1701 OU 1701
Code No. 1293/PCI

7 Discuss E1 and E2 elimination reactions with mechanism and stereochemistry.
Explain generation, structure, stability and reactions of free radicals.
8 Discuss any eight guidelines for disconnection of molecules with simple
examples.
Write the stops involved in the synthesis of
Antipyrin Metronidazole Mercaptopurine