FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) II-Semester (Suppl.)
Examination, February 2019
Subject: Computer Aided Drug Design
Time 3 Hours Max. Marks: 75
Note: Answer any Five questions. All questions carry equal marks
1. What is QSAR? Describe the physicochemical parameters used in QSAR.
Explain how hydrophobicity constant and Hammet comnstants of a substituent
are measured experimentally?
2. Discuss in detail about Hansch analysis and its applications.
Write a note on 3D QSAR studies.
3. What is quantum mechanics? Describe the use of quantum mechanics in drug
design.
What is molecular docking? Discuss the general method of molecular docking.
4. Describe the steps involved in Homology modeling of a protein.
Discuss the concept of predicting ADMET properties and its importance in drug
design.
5. What is known as pharmacophore? Discuss the concept of Pharmacophore based
virtual screening.
Write a note on Similarity based Virtual screening
6. Write a note on Scoring techniques in Molecular docking.
Write a note on Fragment based drug design.
7. What is virtual screening? Enumerate various virtual screening techniques.
Write a note on Privileged structures.
8. Discuss the importance of molecular Mechanics in drug design.
What is Free Wilson analysis? What are the advantages and disadvantages
over hansch analysis?