FACULTY OF PHARMACY
M. Pharmacy (Pharm. Chemistry) II-Semester (Suppl.) Examination,
February 2019
Subject Advanced Organic Chemistry-II
Time: 3 Hours Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 Discuss the Principle and applications of microwave irradiation reactions
Explain the basic principles of green chemistry in organic synthesis.
2 Discuss asymmetric synthesis using chiral pool, chiral auxiliaries, chiral catalysts and
chiral solvents with suitable examples
3 Write a note on transition metal catalysed reactions in organic synthesis
What is biocatalysis? Describe the organic synthesis by using enzymes.
Discuss hydrogenation reactions using homogenous catalysts.
4. Discuss electro cyclic and sigma tropic reactions in presence of heat and light with
suitable examples
5. Write a note on solid phase combinatorial synthesis.
Discuss Various solid supports, linkers, protecting and deprotecting groups used in
solid-phase peptide synthesis
6. Discuss any two methods of resolution of racemic mixtures. 9
Discuss sequence rules of R S configuration with suitable examples. Explain
how it is different from Fisher's D L notations? 6
7. Write a note on
Photo addition reactions
Phase transfer catalysis
Ultra sound assisted reactions
8. Discuss cycloaddition reactions with mechanism and stereochemistry in
presence of heat and light.
Discuss coupling reactions in peptide synthesis