BP 102 T
Professional Course Examination, November 2018
CBCS
1st Semester
BACHELOR OF PHARMACY
Pharmaceutical Analysis—I
Full Marks 75
Time 3 hours
The figures in the margin indicate full marks for the questions
I. Choose the correct answer of the following 1×20=20
1. "Acid is a compound that gives ions in water and base is a
compound that gives OH- in water." This is the theory of
Arrhenius
Lewis
Bronsted
Lowry
2. The strength of an acid depends upon
the conc. of ions in aqueous solution
the conc. of electron pairs in aqueous solution
the tendency to release the electron pair
the tendency to gain the electron pair
/476 1 Contd.
3. The dissociation constant of an acid HA is given by
Ka
H A
HA



Ka
H A
HA



2 2
Ka
H A
HA



2
Ka
H A
HA



2
4. Which is correct about pH?
pH log
pH
pH =10-pH
All of the above
5. Acetic acid is a week electrolyte, because
its molecular mass is high
it exists as dimer
it is highly unstable
it has low ionization
/476 2 Contd.
6. The Henderson-Hasselbalch equation for a week acid and its salt is
pKa pH log
pH pKa log
pH pKa log
pH pKa log
7. The ionic product of water at 25°C is
10-14
10-24
10-16
10-20
8. When ionization is repressed by the addition of its salt, the
phenomenon is called
buffer action
repression
equilibrium
common-ion effect
9. The indicator used for the titration of NaOH and potassium hydrogen
phthalate is
phenolphthalein
methyl orange
methyl red
Both and
/476 3 Contd.
10. pH is equivalent to pKa at
pH 7
pH 1
pH 14
half neutralization point
11. Which of the following is polyprotic acid?
H2SO4
H3PO4
H2CO3
All of the above
12. Ka refers to
dissociation constant of weak acid
dissociation of weak base
dissociation constant of strong acid
None of the above
13. Solution which resists the change in pH is called
acidic solution
alkaline solution
neutral solution
buffer solution
/476 4 Contd.
14. Quinonoid theory of indicator is based on
ionization of indicators
existence of tautomeric forms
Both and
None of the above
15. Aprotic solvents
have high dielectric constant
do not favour ionization
react with acids and bases
are conjugate bases
16. Which method of titration is used for the estimation of drugs
containing primary aromatic amino group?
Non-aqueous titration
Redox titration
Diazotization titration
Complexometric titration
17. In potentiometry, curve is obtained by plotting
e.m.f. vs. ml of titrant
e.m.f. vs. current
current vs. ml of titrant
current vs. resistance
/476 5 Contd.
18. In polarography, the diffusion current at its limiting value using DME
is given by
Nernst equation
Ilkovic equation
Newton's equation
None of the above
19. Disodium edentate solutions can be standardized using
calcium chloride only
zinc sulphate
Both and
iron salts
20. The pM indicator is
a dye
a chelate with unique color
a dye which forms complex with metal
polyvalent metal ion
/476 6 Contd.
II. Answer any seven of the following questions 7×5=35
1. Define standard solution. Write the requirements to be fulfilled for
primary standard.
2. Write the basic principles and application of diazotization titration.
3. Write briefly about the iodometric and iodimetric titrations. Give
examples.
4. What are strong acids and week acids? Explain in detail the theories of
acid-base indicators.
5. Write the working principle and application of polarography.
6. Discuss the principle and applications of Volhard's method in
precipitation titration.
7. Write a note on acidimetry in non-aqueous titrations.
8. Explain in detail the types of EDTA complexometric titration.
9. What are errors? Classify them with examples.
III. Answer any two of the following questions 10×2=20
1. Describe various steps involved in gravimetric analysis.
2. Explain various types of titration curve in neutralization titrations.
3. Write the procedure for standardization of sodium hydroxide
solution and sodium thiosulphate solution.