BPH/III/20
Professional Course Examination, November 2018
Pre-CBCS
3rd Semester
BACHELOR OF PHARMACY
Paper No. 20
Physical Pharmacy—I
Full Marks 40
Time 2 hours
The figures in the margin indicate full marks for the questions
Answer any eight questions
1. Explain eutectic mixtures with examples. Write its applications in dosage
form design.
2. What are cocrystals? Give examples. 2
What are monotropic and enantiotropic systems? Give examples. 3
3. How will you assess the flow properties of pharmaceutical powders?
Outline measures to improve flow properties of tablet granules.
4. What do you mean by buffered isotonic solutions? Outline the methods of
isotonicity measurement. Explain any one method of adjusting isotonicity
of parenterals.
/488 1 Contd.
5. Name the types of bonding possible during binding of drugs to blood
components. Explain the factors affecting plasma protein binding of drugs.

6. Explain any one method of preparation of b-cyclodextrin molecular
inclusion complexes of drugs. Name the methods of analysis of complexes.

7. Illustrate with a diagram the relationship between zeta potential and
surface potential of solid particles in a suspending liquid. Write two
applications of association colloids.
8. Differentiate between ideal and real solutions. How will you determine the
molecular weight of an unknown substance by boiling point elevation
method?
9. Why is it necessary to assess number and weight distribution of solid
particles? With a labeled diagram, discuss the air-permeability method for
determination of surface area of powders.
10. Write short notes on any two of the following 2½×2=5
Debye-Huckel theory
Drug crystallinity and polymorphism
Flocculated and deflocculated suspensions