BPH/V/40
Professional Course Examination, November 2018
Pre-CBCS
5th Semester
BACHELOR OF PHARMACY
Paper No. 40
Pharmacology—II
Full Marks 40
Time 2 hours
The figures in the margin indicate full marks for the questions
Answer Question No. 1 and any seven from the rest
1. Choose the correct answer of the following ½×10=5
The effect of cardiac glycoside is increased if
plasma potassium ion decreases
plasma potassium ion increases
plasma sodium ion decreases
plasma sodium ion increases
The special feature of class III antiarrhythmic drug is
to reduce the cardiac action potential duration
to prolong the cardiac action potential duration
to decrease the cardiac resting membrane potential
to elevate the cardiac resting membrane potential
/494 1 Contd.
The safest drug for therapy of hypertension during pregnancy is
methyldopa
amlodipine
telmisartan
enalapril
The suitable drug for management of acute attack of angina is
verapamil
atenolol
glyceryl trinitrate
isosorbide mononitrate
Iron is stored in our body by combining with large protein called
transferrin
ferroprotein
apoferritin
ferritin
Select the anticoagulant which produces action by activating
antithrombin III
lepirudin
warfarin
heparin
sodium citrate
Triphasic response in blood pressure is the characteristic of
leukotriene
prostaglandin E2
histamine
serotonin
/494 2 Contd.
The main function of histamine H2 receptor is
to control acid secretion in stomach
to act as auto receptor in CNS
to produce allergic reaction
to facilitate chemotaxis
Which of the following antiasthmatic drugs is having both
bronchodilation and anti-inflammatory actions?
Zileuton
Salmeterol
Aminophylline
Montelukast
Which of the following diuretics produces effect by blocking
Na 2Cl- symport?
Acetazolamide
Furosemide
Hydrochlorothiazide
Spironolactone
2. Classify antihypertensive drugs with example. Write the mechanism of
action and major side effects of enalapril or methyldopa.
3. Discuss the details of cardiac effect of digitalis including electrophysiological
properties. 5
4. Briefly discuss the types of sodium channel blockers with example and
their role as antiarrhythmic. 5
5. Why does deficiency of iron cause anaemia? Explain the absorption,
transportation, storage and daily turnover of iron in our body.
6. Explain the therapeutic significance of antiplatelet drugs. Classify
antiplatelet drugs with example.
/494 3 Contd.
7. Write the mechanism of action, use and side effects of acetazolamide. 5
8. Explain the endogenous release of histamine. What are different histamine
receptors? Explain triple response of histamine.
9. What do you mean by eicosanoids? Write the different receptors of PGE2
and explain the pharmacological action mediated through these receptors.

10. What do you mean by antitussives and expectorants? Give a brief
classification of drugs with example used in symptomatic treatment of
cough.