FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2017

POSSESSION USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
BIOCHEMISTRY
PAPER III
Time 3 hours BIO/D/17/03/III
Max. Marks 100
Important instructions:
• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two
answers.
• Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Role of chaperones in protein folding and diseases
associated with protein misfolding.
6+4
2. Define mutation, different types and its manifestations.
3. DNA damage and repair mechanisms, and clinical
aspects.

4. Monoclonal antibody, their uses and related clinical
aspects.
6+4
5. Immunological tests for thyroid functions.
10
6. Explain tumour index substances, their role in diagnosis
and prognosis.
6+4
7. Telomerase activity in ageing.
Anticancer drugs influencing cell cycle.
5+5
8. Apoptosis
Immunological memory
5+5
9. Cell mediated immunity
Complement system
5+5
10. Mitochondrial DNA
Protein targeting
5+5