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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI 600 034
M.Sc. DEGREE EXAMINATION BIOTECHNOLOGY
THIRD SEMESTER NOVEMBER 2017
16PBT3ES02 CANCER BIOLOGY
Date: 10-11-2017 Dept. No. Max. 100 Marks
Time: 09:00-12:00
PART A
Answer ALL the Questions
I. Choose the correct answer x 1 5 Marks)
1. In which phase of cell cycle synthesis of DNA takes place
S phase G0 G1 M phase
2. Which is the predominant cancer in Women?
Lung Breast Endometrial Skin
3. Which is a chemical mutagen?
EMS X-rays Beta rays Gamma rays
4. Inflamation in cancer is due to the presence of what?
Interleukins Cytokines Interferons Antigenic peptides
5. Arrangement of alleles on a chromosome is called .
Haplotype Genotype Phenotype heterotype
II. State whether the following are true or false. (5x1=5 Marks)
6. Cdk is involved in cell cycle.
7. Second messengers are present in MAPK pathway.
8. OH radicals can be prevented by taking antioxidants.
9. C-onc is expressed during normal embryonic development.
10. PCR is used for the molecular diagnosis of cancer.
III. Complete the following x 5 Marks)
11. Nerve cells are always in phase of cell cycle.
12. EPO pathway is also called as
13. NIH3T3 is a cell line.
14. islands methylation occur in cancer.
15. MRI is used for cancer.
IV. Answer the following within 50 words x 1 5 Marks)
16. Define Metastasis.
17. What is the significance of CD40?
18. What is an antigenic peptide?
19. What is the cause of inflammation in cancer?
20. Define haplotype.
PART B
Answer the following each within 500 words. x 8 40 marks)
Draw diagrams wherever necessary
21. (a)Discuss apoptosis and cancer.
OR
(b)Explain the experimental models used for the study of carcinogen.
22. Write briefly about prostate and endometrial cancers.
OR
Explain cancer stem cells and its therapeutic implications.
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23. Comment about inflammation occurring during cancer.
OR
Discuss heat shock proteins as regulators of immune response.
24. (a)Explain RNAi pathway used for cancer treatment.
OR
Explain mechanism of hormonal induced cancer.
25. Explain 2D electrophoresis used for the separation of tumour protein markers.
OR
Write an account on ultra sound imaging.
PART C
Answer any TWO of the following, each within 1500 words. x 20 40 Marks)
Draw diagrams wherever necessary.
26. Describe angiogenesis factors and its inhibitors used in cancer therapy.
27. Explain protein coupled signal transduction in cancer cells.
28. Discuss chemical carcinogenesis.
29. Write in detail about molecular mechanism of ageing and prevention.