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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI 600 034
M.Sc. DEGREE EXAMINATION BIOTECHNOLOGY
THIRD SEMESTER NOVEMBER 2017
16PBT3MC03 RESEARCH METHODOLOGY AND BIOINFORMATICS
Date: 06-11-2017 Dept. No. Max. 100 Marks
Time: 09:00-12:00
PART A
Answer ALL the Questions
I. Choose the correct answer x 1 5 Marks)
1. Process of randomly selecting intact groups within defined population sharing similar characteristics
Stratified sampling Cluster sampling
Systematic sampling Random sampling
2. What type of graph would you use to see the distribution of a scale variable?
Bar chart Pie chart
Histogram Scatterplot
3. The database that houses experimentally determined structures is
a)UniprotKB b)PDB
c)SCOP d)CATH
4. Choose the heuristic based approach to study alignment
EMBOSS NEEDLE EMBOSS WATER
BLAST ProFam
5. Which of the following tool is uses Parsimony to build phylogenetic tree.
Phylogeny.fr b)PAUP
PHYLIP MEGA
II. State whether the following are true or false. (5x1=5 Marks)
6. Nominal data is also called as variable data.
7. Advantage of using syntax is that it can be saved and retrieved for subsequent analyses.
8. ARSA can be used to search DDBJ if accession number is unknown.
9. Homoplasy is a result of convergent evolution.
10. The Jukes Cantor model assumes that all nucleotides occur at equal frequency.
III. Complete the following x 5 Marks)
11. an offline source of literature.
12. The difference between the largest and the smallest observations is called
13. Webin is a web based sequence submission tool
14. is a gene prediction tool that predicts almost 80% exons in human genes.
15. is a branching hierarchical tree that shows the relationship between clades.
IV. Answer the following within 50 words x 1 5 Marks)
16. What is exploratory redearch?
17. Write a note on t-test.
18. What is the role of INSDC?
19. Mention the importance of Clustal Omega.
20. Define phylogenetics.
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PART B
Answer the following each within 500 words. x 8 40 marks)
Draw diagrams wherever necessary
21. Enumerate the different objectives of research.
OR
Give a note on sampling and its types.
22. Write about the SPSS software in statistics.
OR
Give a short note on spatial statistics.
23. (a)Write an account on sequence retrieval systems and sequence submission tools.
OR
Give an account on the flat file format of Genbank.
24. Compare the dynamic programming algorithm used for sequence analysis.
OR
Write briefly about scoring matrix and its importance in sequence alignment.
25. Illustrate UPGMA method of tree building.
OR
(b)Explain the neutral theory of evolution.
PART C
Answer any TWO of the following, each within 1500 words. x 20 40 Marks)
Draw diagrams wherever necessary.
26. Explain in detail the components of a research proposal.
27. Describe the different methods of representation of data.
28. Write an essay on the various biological databases.
29. Elaborate on the different gene finding methods.