B.Pharmacy (Semester Examination, 2017
SOLID DOSAGE FORMS
Day and Date Thursday, 4-5-2017 Total Marks 80
Time 10.30 a.m. to 1.30 p.m.
1. MCQs. 16
Durability of a tablet to combined effects of shock and abrasion is evaluated
by using
Hardness tester Disintegration test apparatus
Friabilator Screw gauge
Sealing of capsule is achieved by
100°C 20°C
37 − 40°C 70 − 80°C
Enteric coated tablet is disintegrated in
Stomach Mouth Intestine Liver
Which of the following materials offers moisture barrier properties
Aclar Cellophane
Polyester All of the above
Unequal distribution of color on a tablet refers to
Capping Mottling Picking Sticking
The first and most widely used diluent in tablet formulation is
Dextrose Lactose
MCC Starch
Which of the following is a water soluble lubricant
Stearic acid Mineral oil
PEG Magnesium stearate
Enteric coated tablet disintegrate in hr. in simulated intestinal
fluid.
1 2 3 4
Friabilator is operated at
100 rpm 75 rpm 50 rpm 25 rpm
10) In tablet coating process, inadequate spreading of coating solution before
drying causes
Orange peel effect Sticking effect
Blistering effect Picking effect
11) Objective of tablet layout design is
Avoid theft Minimise contamination
Minimise process coast All of the above
12) is physical method of microencapsulation.
Polymerization Air suspension techniques
Both a and b None of the above
13) method of microencapsulation is suitable for solid alone.
Pan coating Solvent evaporation
Spray drying and spray congealing All of the above
14) water soluble coating material.
Gelatin Starch
Hydroxy ethyl cellulose All of the above
15) material is used in pharmaceutical packaging.
Glass Plastic
Metal All of the above
16) Major disadvantages of glass as packaging agent
Fragility Weight
Both a and b None
2. Answer any four
Classify microencapsulation technique with example.
Give an account on in process quality control test for capsule shell.
Enlist 4 objective of layout of tablet manufacturing section.
Write a note on film formers
Which type of drugs are suitable for direct compression.
Give an account on evaluation of granules.
3. Answer any two
Write a note on wet granulation.
Give detailed account on capsule manufacturing by rotary die process.
Write a note on phase separation-coacervation technique. Give advantages
and disadvantages of the same.
4. Answer any four
Give an account on disintegrants used in tablets.
Give four advantages of sugar coating.
Write a note on process of manufacturing gelatin used in capsules.
Explain disintegration test for hard gelatin capsule.
Write a note on air suspension microencapsulation process.
Enlist chemical microencapsulation technique explain any one in detail.
5. Answer any 2
Write a note on sugar coating.
Explain weight variation test for uncoated tablets.
Enlist quality control test for capsules and explain any one official test in
detail.