M.Sc. (Semester II) (CBCS) Examination, 2017
BIOINFORMATICS
CANCER GENETICS AND STEAM CELL RESEARCH
Day Date: Friday, 28-04-2017 Max. Marks: 70
Time: 10.30 AM to 01.00 PM
Instructions: Section I is compulsory.
From Section II attempt any four
All questions carry equal marks.
Figures to the right indicate full marks.
Draw neat and labeled diagrams
Section I
Q.1 Rewrite the following sentences by using correct alternatives 07
Totipotancy is the ability of stem cells.
Mesenchymal Hematopoietic
Adult stem cell Embryonic
Hematopoietic steam cells are cell.
Unipotant Totipotant Pluripotant Embryonic
Regulation of epithelial and mesenchymal interactions is carried out
by
Platelet Derived Growth Factor- Goblet growth factor
Zymogenic factor Tumor Necrotic factor
The ability to invade surrounding tissue and is main
hallmark of cancer
Regeneration Replication
Metastasis Motility
is inhibitory protein of p53
p27 Mdm2 p21 X-rays
proteins act like a spool that DNA can be wound around to
become more compact.
Histone Nuclease Protease Helicase
The proteases system involved in apoptosis pathway is called as

Caspases CD molecules
p53 TGF-B
Page 1 of 2
Definitions: 07
Epigenetics
Oncogene
Embryonic stem cell
Benign tumor
Hematopoietic Stem Cells
Carcinogenes
Extra Cellular Matrices
Section II
Answer any four of the following:
Q.2 Discuss in detail Tumor suppressor gene. 14
Q.3 Explain in detail isolation of stem cells from tissue. 14
Q.4 Explain in detail event of angiogenesis. 14
Q.5 Answer any two of the following: 14
Write on Mesenchymal Stem Cells
Give details mechanism of Metastatic cascade
Discuss Radiation Therapy
Q.6 Answer any two of the following: 14
Write a short note on Transplantation Technique.
Explain Epigenetics in cancer
Add a note on physical carcinogens.