P.G. DIPLOMA IN STRUCTURAL
PHARMACOGENOMICS EXAMINATION,
DECEMBER 2017
First Semester
Bioinformatics
Elective I — IMMUNOINFORMATICS
(CBCS 2013 onwards)
Time 3 Hours Maximum 75 Marks
Part A (10 x 2 20)
Answer all questions.
All questions carry equal marks.
1. Fc receptor
2. Opsonin
3. IgE
4. Anti idiotype Antibodies
5. Immunogenomics
6. HLA-B
7. Autoimmunity
8. MHC class III
9. MHC ligands
10. Alignments.
Sub. Code
510501
RW-1396
2
Wk 3
Part B x 5 25)
Answer all questions.
All questions carry equal marks.
11. Explain the concepts of antigen processing and
presentation with a suitable example.
Or
Enumerate the advantages and disadvantages of
monoclonal antibodies.
12. Describe the various factors responsible for
autoimmunity.
Or
Give an account on B cell surface receptor for
antigen.
13. Explain toxoids and how are they used in
vaccination.
Or
Comment on IMGT/HLA sequence database.
14. Explain the mathematical models of HIV.
Or
Write a short note on MHC polymorphism.
15. Give an account on Epitopes databases.
Or
Explain the uses of predicting 3D structure in
antibody homology modeling.
RW-1396
3
Wk 3
Part C x 10 30)
Answer any three questions.
All questions carry equal marks.
16. Write an essay on humoral and cellular immunity.
17. Discuss the functions of class I and II MHC Molecules.
18. Give a brief account on Vaccine design and application of
therapeutic vaccines.
19. Give a detail note on viral informatics with suitable
example.
20. Explain the various methods applied in immunological
bioinformatics tools.
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