P.G. DIPLOMA IN STRUCTURAL
PHARMACOGENOMICS EXAMINATION,
DECEMBER 2017
First Semester
Bioinformatics
MOLECULAR CELL BIOLOGY AND GENETIC
ENGINEERING
(CBCS 2013 onwards)
Time 3 Hours Maximum 75 Marks
Part A (10 x 2 20)
Answer all questions.
All questions carry equal marks.
1. Define Gene.
2. What is meant by cell signaling?
3. Senescence.
4. Mutations.
5. Genetic code.
6. Capping and Splicing.
7. Transposons.
8. Define vectors with examples.
Sub. Code
510101
RW-1390
2
ws 4
9. What is site-directed mulagenesis?
10. Phasmids.
Part B x 5 25)
Answer all questions.
All questions carry equal marks.
11. Differentiate between prokaryotic and eukaryotic
cells.
Or
Explain about mitosis with suitable diagram.
12. State the different types of DNA mutations with
example.
Or
Explain the various types of transport across the
biological membrane in the cell.
13. Explain about the post transcription process in the
eukaryotic cells.
Or
Describe the three types of RNA's involved in the
translation process.
14. Explain the mechanism of transcription with its
factors.
Or
Describe the construction mechanism of cDNA
library.
RW-1390
3
ws 4
15. Briefly explain the rDNA technology for human
welfare.
Or
Define restriction enzymes and explain its types
with example.
Part C x 10 30)
Answer any three of the following.
16. Describe the major cellular organelles with their
structure and functions along with suitable diagrams.
17. Discuss about the replication of DNA in eukaryotic cells.
18. Give a detailed account of Human genome project.
19. Elaborate-transformation, transduction and conjugation.
20. Define vector? Explain about the different types of
vectors used in cloning.
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