M.Sc. (Semester III) (CBCS) Examination Oct/Nov-2017
Bioinformatics
MOLECULAR MEDICINE
Day Date: Tuesday, 21-11-2017 Max. Marks: 70
Time: 02.30 PM to 05.00 PM
Instructions: All questions of Section I are compulsory.
Answer any four questions from section II
All questions carry equal marks.
Draw neat and labeled diagrams wherever necessary.
SECTION I
Q.1 Rewrite the sentence after choosing the correct answer from the
given alternatives:
07
Mutation in BTK gene leads to condition known
Phenylketonuria Haemoglobinopathies
Agammaglobulinemia Marfan syndrome
is defined as compounded that demonstrates the desired
biological activity on molecular target.
Lead Genome
Mercury Iron
linked recessive disease.
DMD CFTR
BTK Marfan
Stem cell exhibits properties.
Only potency Potency and self renewable
Potency and non renewable Only self-renewable
The human gene of haemoglobin is located on chromosome

11 12
16 18
Hematopoietic stem cells
Pluripotent Totipotent
Unipotent Oligopotent
PAH gene is mutated in
Phenylketoneuria Chagas disease
Alzhemer's Cystic fibrosis
Definitions 07
Totipotency.
Recombination.
Microarray.
Lead optimization.
Magic bullets.
Down's syndrome.
Functional cloning.
Page 2 of 2
SLR-MC-78
SECTION II
Answer any four of the following
Q2 Define absorption. Explain in detail factor affecting absorption and add a note
on pharamacogenetics.
14
Q3 Explain in detail viral and non viral methods of gene transfer. 14
Q4 Explain In brief properties, types and applications of adult stem cells. 14
Q5 Answer any two of the following 14
Give an account on phenylketonuria.
Explain in brief gammaglobelinemia.
Give an account on human genome project.
Q6 Answer any two of the following 14
Chorionic villus sampling and its applications.
Blood and blood group antigens.
Parkinson's disease.