Exam Details
| Subject | bio-organic chemistry and drug design | |
| Paper | ||
| Exam / Course | b. pharmacy | |
| Department | ||
| Organization | savitribai phule pune university | |
| Position | ||
| Exam Date | April, 2018 | |
| City, State | maharashtra, pune |
Question Paper
T.Y. B. PHARMACY (VI Semester) EXAMINATION, 2018
BIO-ORGANIC CHEMISTRY AND DRUG DESIGN
(2015 PATTERN)
Time Three Hours Maximum Marks 60
N.B. All questions are compulsory.
(ii Answers to the two sections should be write in separate
answer-books.
(iii Figures to the right indicate full marks.
Section-I
1. Explain physiological role of Cyclooxygenase 1 and 2 and its relevance
in drug design. Comment on their inhibitors.
Or
What is molecular recognition Explain the process of molecular
recognition emphasizing the interactions involved in molecular
recognition.
2. Attempt any four of the following
Explain biochemical role of HMG CoA reductase and its relevance
in drug design.
Write a note on molecular adaptation.
Write a note on antisense therapy.
Write a note on chain terminators in DNA strand breaking.
Explain the term proximity effect.
Write a note on tyrosine kinase inhibitors.
Elaborate on MAO enzyme and its antagonist.
[5345]-6006 2
3. Attempt any two of the following
Explain the mechanism of alkylating agents targeting the nucleic
acid.
Write a note on adrenergic receptors and its agonist.
Explain the mechanism of intercalation of DNA with example.
Explain the structure and physiological role of GABA A receptor.
Section-II
4. Write in detail about Quantum Mechanics and Methods used
in QM calculations.
Or
Explain lead discovery and methods of lead optimization.
5. Attempt any four of the following
Explain concept and applications of QSAR.
Write about CoMFA.
Write a note on Mechanism-based drug design.
Explain Free-Wilson method in QSAR.
Give basic objectives of prodrug design and explain need of
developing prodrug.
Explain ligand-protein interactions observed in molecular docking.
Write a note on Drug Discovery and Drug Design.
6. Attempt any two of the following
Discuss different approaches to the rational design of enzyme
inhibitors.
Write the physicochemical parameters in QSAR.
Explain briefly about steric parameters used in QSAR.
Define the term Give detailed account on types of
prodrug design with suitable examples.
BIO-ORGANIC CHEMISTRY AND DRUG DESIGN
(2015 PATTERN)
Time Three Hours Maximum Marks 60
N.B. All questions are compulsory.
(ii Answers to the two sections should be write in separate
answer-books.
(iii Figures to the right indicate full marks.
Section-I
1. Explain physiological role of Cyclooxygenase 1 and 2 and its relevance
in drug design. Comment on their inhibitors.
Or
What is molecular recognition Explain the process of molecular
recognition emphasizing the interactions involved in molecular
recognition.
2. Attempt any four of the following
Explain biochemical role of HMG CoA reductase and its relevance
in drug design.
Write a note on molecular adaptation.
Write a note on antisense therapy.
Write a note on chain terminators in DNA strand breaking.
Explain the term proximity effect.
Write a note on tyrosine kinase inhibitors.
Elaborate on MAO enzyme and its antagonist.
[5345]-6006 2
3. Attempt any two of the following
Explain the mechanism of alkylating agents targeting the nucleic
acid.
Write a note on adrenergic receptors and its agonist.
Explain the mechanism of intercalation of DNA with example.
Explain the structure and physiological role of GABA A receptor.
Section-II
4. Write in detail about Quantum Mechanics and Methods used
in QM calculations.
Or
Explain lead discovery and methods of lead optimization.
5. Attempt any four of the following
Explain concept and applications of QSAR.
Write about CoMFA.
Write a note on Mechanism-based drug design.
Explain Free-Wilson method in QSAR.
Give basic objectives of prodrug design and explain need of
developing prodrug.
Explain ligand-protein interactions observed in molecular docking.
Write a note on Drug Discovery and Drug Design.
6. Attempt any two of the following
Discuss different approaches to the rational design of enzyme
inhibitors.
Write the physicochemical parameters in QSAR.
Explain briefly about steric parameters used in QSAR.
Define the term Give detailed account on types of
prodrug design with suitable examples.
Other Question Papers
Subjects
- active pharmaceutical ingrendients technology
- analytical pharmacognosy and
- analytical pharmacognosy and extraction technology
- bio-organic chemistry and drug design
- communication and soft skill development
- dosage form design
- extraction technology
- human anatomy and physiology–i
- human anatomy and physiology—ii
- industrial pharmacy—i
- industrial pharmacy—ii
- medicinal chemistry–i
- modern dispensing practices
- natural product chemistry
- pharmaceutical analysis-iii
- pharmaceutical analysis—i
- pharmaceutical analysis—iv
- pharmaceutical biochemistry
- pharmaceutical business management and disaster management
- pharmaceutical engineering
- pharmaceutical inorganic chemistry–i
- pharmaceutical microbiology
- pharmaceutical organic chemistry-iv
- pharmaceutical organic chemistry—i
- pharmaceutical organic chemistry—ii
- pharmaceutical organic chemistry—iii
- pharmaceutics-i
- pharmaceutics–ii
- pharmacognosy
- pharmacognosy & phytochemistry—i
- pharmacognosy and phytochemistry–ii
- pharmacology—ii
- pharmacology—iii
- physical pharmaceutics-i