Exam Details
| Subject | medicinal chemistry–i | |
| Paper | ||
| Exam / Course | b. pharmacy | |
| Department | ||
| Organization | savitribai phule pune university | |
| Position | ||
| Exam Date | April, 2018 | |
| City, State | maharashtra, pune |
Question Paper
T.Y. B. Pharmacy Sem.) EXAMINATION, 2018
MEDICINAL CHEMISTRY-I
(2015 PATTERN)
Time Three Hours Maximum Marks 60
N.B. All questions are compulsory.
(ii Answers to the two sections should be written in separate
answer sheets.
(iii Write neat structures and diagrams wherever necessary.
Figures to the right indicate full marks.
SECTION I
1. Discuss the role of solubility, partition coefficient and hydrogen bonding
on drug action citing suitable examples under each parameter.
Or
What are antihypertensive agents Classify them giving the structure
and IUPAC of at least one drug belonging to each class. Discuss
in detail the calcium channel blockers.
2. Attempt any four questions. Each question carries 3 marks.
Write about various sites of pre-systemic metabolism
Write structure and uses of
Guanethidine
(ii Salbutamol
P.T.O.
[5345]-5003 2
Discuss any one HMGCoA reductase inhibitor in detail.
Write about Glucuronide conjugation in drug metabolism
Write a note on neuromuscular blocking agents.
Give an account of forces involved in drug receptor interaction.
Explain how partition coefficient affects drug action.
3. Solve any two questions. Each question carries 4 marks.
How bioisosterism affects drug design
Enumerate the structural features essential for directly acting
sympathomimetic agents.
Write a note on cardiac glycosides.
Discuss in detail the irreversible AchE inhibitors.
SECTION II
4. What are the various types of receptors Discuss each type in
detail with the help of examples and neat diagrams.
Or
What are sympathomimetics Discuss the structural features important
for such agents giving examples.
5. Attempt any four questions. Each question carries 3 marks.
Write a note on stereochemistry of Ach.
Differentiate passive and active transport.
Give the scheme of synthesis for prazosin.
Write a note on potassium sparing diuretics.
[5345]-5003 3 P.T.O.
Discuss the SAR of cholinomimetics.
Discuss any one adrenergic receptor blocking agent.
Write the scheme of synthesis for clofibrate.
6. Solve any two questions. Each question carries 4 marks.
Discuss various theories designed to explain drug receptor
interaction.
Write a note on rennin-angiotensin system. Discuss any one
ACE inhibitor.
Write the structure and uses of carbonic anhydrase inhibitors.
Classify adrenergic receptors and comment on their importance.
MEDICINAL CHEMISTRY-I
(2015 PATTERN)
Time Three Hours Maximum Marks 60
N.B. All questions are compulsory.
(ii Answers to the two sections should be written in separate
answer sheets.
(iii Write neat structures and diagrams wherever necessary.
Figures to the right indicate full marks.
SECTION I
1. Discuss the role of solubility, partition coefficient and hydrogen bonding
on drug action citing suitable examples under each parameter.
Or
What are antihypertensive agents Classify them giving the structure
and IUPAC of at least one drug belonging to each class. Discuss
in detail the calcium channel blockers.
2. Attempt any four questions. Each question carries 3 marks.
Write about various sites of pre-systemic metabolism
Write structure and uses of
Guanethidine
(ii Salbutamol
P.T.O.
[5345]-5003 2
Discuss any one HMGCoA reductase inhibitor in detail.
Write about Glucuronide conjugation in drug metabolism
Write a note on neuromuscular blocking agents.
Give an account of forces involved in drug receptor interaction.
Explain how partition coefficient affects drug action.
3. Solve any two questions. Each question carries 4 marks.
How bioisosterism affects drug design
Enumerate the structural features essential for directly acting
sympathomimetic agents.
Write a note on cardiac glycosides.
Discuss in detail the irreversible AchE inhibitors.
SECTION II
4. What are the various types of receptors Discuss each type in
detail with the help of examples and neat diagrams.
Or
What are sympathomimetics Discuss the structural features important
for such agents giving examples.
5. Attempt any four questions. Each question carries 3 marks.
Write a note on stereochemistry of Ach.
Differentiate passive and active transport.
Give the scheme of synthesis for prazosin.
Write a note on potassium sparing diuretics.
[5345]-5003 3 P.T.O.
Discuss the SAR of cholinomimetics.
Discuss any one adrenergic receptor blocking agent.
Write the scheme of synthesis for clofibrate.
6. Solve any two questions. Each question carries 4 marks.
Discuss various theories designed to explain drug receptor
interaction.
Write a note on rennin-angiotensin system. Discuss any one
ACE inhibitor.
Write the structure and uses of carbonic anhydrase inhibitors.
Classify adrenergic receptors and comment on their importance.
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Subjects
- active pharmaceutical ingrendients technology
- analytical pharmacognosy and
- analytical pharmacognosy and extraction technology
- bio-organic chemistry and drug design
- communication and soft skill development
- dosage form design
- extraction technology
- human anatomy and physiology–i
- human anatomy and physiology—ii
- industrial pharmacy—i
- industrial pharmacy—ii
- medicinal chemistry–i
- modern dispensing practices
- natural product chemistry
- pharmaceutical analysis-iii
- pharmaceutical analysis—i
- pharmaceutical analysis—iv
- pharmaceutical biochemistry
- pharmaceutical business management and disaster management
- pharmaceutical engineering
- pharmaceutical inorganic chemistry–i
- pharmaceutical microbiology
- pharmaceutical organic chemistry-iv
- pharmaceutical organic chemistry—i
- pharmaceutical organic chemistry—ii
- pharmaceutical organic chemistry—iii
- pharmaceutics-i
- pharmaceutics–ii
- pharmacognosy
- pharmacognosy & phytochemistry—i
- pharmacognosy and phytochemistry–ii
- pharmacology—ii
- pharmacology—iii
- physical pharmaceutics-i