S.Y. B. PHARMACY (IV Semester) EXAMINATION, 2018
PHARMACEUTICAL ORGANIC CHEMISTRY-IV
(2015 PATTERN)
Time Three Hours Maximum Marks 60
N.B. Answers to the two sections should be written in separate
books.
(ii Figures to the right indicate full marks.
(iii All questions are compulsory.
Section-I
1. Give a detail account of methods of synthesis and reactions of
Pyridine.
Or
Give the structure, numbering of the following heterocycles with
one example of drug belonging to each
Hydantoin
Isoxazole
Pyridazine
Coumarin
Pyrrole.
2. Solve any four
Why furan undergoes electrophilic substitution reactions
preferentially at C-2 and C-5
[5345]-4003 2
Give the structure of the following
2,6-diethoxypyridine
(ii Propyl-3-ethylfuran-2-carboxylate
(iii 7-(methoxymethyl) quinoline
Give resonance structures of pyrrole and its one method of
synthesis.
Why quinoline gives electrophilic aromatic substitution at
C-5 and C-8
Explain acidic and basic character of imidazole.
Give any two methods of synthesis of pyrrole.
Give any two reactions of thiophene.
3. Write short notes on (any two)
Reactions of Pyrrole
Furan
Quinoline
Anthracene.
Section-II
4. Explain basic principle of Microwave assisted synthesis. Add a note
on techniques of microwave assisted synthesis and applications of
microwave assisted synthesis in pharmaceutical organic
chemistry.
Or
What is combinatorial synthesis Comment on mix and split synthesis
in Combinatorial chemistry. Give applications of Combinatorial
chemistry.
5. Answer the following (any four)
Write rules of disconnection.
[5345]-4003 3 P.T.O.
Give the role of aluminium isopropoxide in organic reactions.
Explain the method of preparation of NBS.
Explain the reactions and uses of diazomethane.
Explain the common terms in retrosynthesis approach.
Explain the method of preparation of DDQ.
Explain the reactions and uses of halogenating agents.
6. Write short notes on (any two)
Objective of retrosynthesis approach.
Deconvolution method in combinatorial chemistry.
Retrosynthesis of Sulfamethoxazole.
DCC.