M.Sc. (Semester (CBCS) Examination Nov/Dec-2018
Genetics
CYTOGENETIC AND GENOME ORGANISATION
Time: 2½ Hours Max. Marks: 70
Instructions: All questions are compulsory.
Figures to the right indicate full marks.
Draw neat and labeled diagrams.
Q.1 Rewrite the sentences by choosing correct answer from given alternatives: 14
of the following will give a normal female Drosophila.
AAA XX AA XXY
AA XY AA +XXX
of the following will you expect plasmids to be absent.
Streptococcus sp Schizosaccharomycespombe
Drosophila Haemophilissp
B chromosome is also called as
Linear chromosome Lineage specific chromosome
Supplementary chromosomes Extra nuclear chromosomes
of the following is untrue about the genome mapping.
It doesn't lead to the understanding a genome structure
It involves identifying relative locations of genes
It involves identifying traits
It involves identifying mutations
of the following is correct statement.
Physical maps are constructed by using a chromosome walking technique
Physical map does not use actual physical distances usually measured in
number of base pairs.
Restriction mapping is not used for physical mapping
Physical map does not illustrate the arrangement of gene of DNA.
The extent of chromosomes coiling in non-dividing cells is
Supercoiled Euchromatin
Condensed Heterochromatin
histone(s) are acted upon by histone acetyltransferase.
H1, H2 H3
H2A, H2B H3, H4
The retroposons include short interspersed nuclear elements
(SINES).
90-4000 bp long 80- 500 Mbp long
80-300 bp long 100-3000 bp long
of human genome comprises one particular family of the SINE
element, designated Alu (1.2 million copies)
10.7% 20.7%
60% 40%
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SLR-VK-309
10) is a maternally inherited neurodegerative disease in humans.
Alzeimer's Parkinson's
LHON Paralysis
11) of the following is not a common mode of histone modification in
eukaryotes?
Methylation Phosphortlation
Sulphonation Ubiquitinylation
12) Physical maps are maps of locations of identifiable landmarks on a genomic
DNA inheritance patterns.
Remotely related to Related to
Regardless of Associated with
13) of the following is not true about plasmids.
They are extrachromosomal DNA
They are double stranded
They confer antibiotic resistance
They may get incorporated in chromosome
14) The XO system of sex determination is found in
Insects Birds
Reptiles Mammals
Q.2 Answer the following any four:-
1. What is constitutive chromain?
2. What is promoter?
3. What is chromosome painting?
4. What are jumping genes?
5. What is genic balance theory?
08
Write notes on (Any
1. Lampbrush chromosome
2. Alu family
3. Microsatellite
06
Q.3 Answer the following Any
1. Write the mechanisms of sex determination in plants.
2. What are LINEs?
3. Describe cytoplasmic inheritance.
08
Answer the following any one
1. Describe the genome organization in prokaryotes.
2. Describe chromosomes structure and its organization
06
Q.4 Answer the following Any
1. What is C-value paradox?
2. Describe plasmid as vector.
3. Describe P-elements in Drosophila.
10
Answer the following any one
1. Describe properties of some well known plasmids.
2. Describe the somatic cell hybridization.
04
Q.5 Answer the following. (Any two) 14
Describe G and R chromosome banding and their applications.
Describe structure of gene in eukaryotes.
Describe the organization of nuclear and organelle genome