B.Sc. II (Semester III) (Biotechnology) (Old CGPA) Examination, 2018
IMMUNOLOGY I
Day and Date Saturday, 28-4-2018 Max. Marks 70
Time 2.30 p.m. to 5.00 p.m.
N. B. All questions are compulsory.
Figures to the right indicate full marks.
Draw neat labelled diagrams wherever necessary.
1. Choose the correct alternative and rewrite the sentence 14
Lysozyme is present in
Saliva Cerebrospinal fluid
Sweat Urine
ii) Passive immunization is done by using
Vaccines Toxoids
Immune sera None of these
iii) Tuberculin test is an example of hypersensitivity.
type I type II type III type IV
iv) is a autoantigen.
Hapten RBCs
Eye lens proteins WBCs
BCG is an example of vaccine.
Killed Live attenuated
Toxoid None of these
vi) In cell mediated immunity will perform role in target cell
killing.
perforins fragmentins
granzymes all of these
vii) is used for fusion of myeloma cells and B lymphocytes in
synthesis of monoclonal antibodies.
PEG Ig HGPRT HAT
viii) Systemic Lupus erythematosus is type of autoimmune
disease.
Organ-specific Organ non-specific
hemolytic None of these
ix) is normal flora of skin.
Staphylococcus aureus Staphylococcus epidermidis
Propionibacterium acne All of these
is primary mediator of anaphylaxis.
Histamine Prostaglandins
Leukotrienes Platelet activating factor
xi) antibody is involved in type I hypersensitivity reactions.
IgM IgG IgD IgE
xii) B cells mature in
Lymphnode Spleen Bone marrow Thymus
xiii) In the A blood group person type of isoantibodies are present.
Anti-A Anti-B Anti-AB Anti-D
xiv) hypersensitivity may involve complement activation, pore
formation and destruction of cells.
Type II Type III
Type IV Type II and III
2. Define and explain any seven of the following 14
Innate immunity and factors influencing innate immunity.
ii) Give names of chemical barriers of Innate Immunity.
iii) Serum sickness.
iv) Applications of monoclonal antibodies.
Give difference between immediate hypersensitivity and delayed type of
hypersensitivity.
vi) T cell receptors.
vii) Define anaphylaxis and atopy.
viii) Give applications of blood group.
3. Answer any two of the following 10
Write in detail immunity to protozoa with an example.
ii) Write in detail physical barriers of Innate immunity.
iii) Write in detail antibody production against T cell dependent and
independent antigens.
Write in brief on 'Hybridoma technology'. 4
4. Answer any two of the following 14
Explain T cell mediated immune response in detail.
ii) Explain in detail traditional vaccines.
iii) Write in detail ABO and Rh blood group systems.
5. Answer any two of the following 14
Explain in detail mechanism of autoimmunity.
ii) Explain in detail immunity to viruses.
iii) Explain in detail phagocytosis and inflammation.