OCTOBER 2017 Sub. Code: 2911
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV PHARMACOLOGY
PAPER II PHARMACOLOGY AND TOXICOLOGY
Q.P. Code: 262911
Time: Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Classify antibiotics based on their site of action with examples. Describe the
mechanism of action, spectrum of activity and therapeutic uses of Macrolide
antibiotics.
2. Define Bio-availability. Explain the various factors affecting bio-availability.
Describe the importance of bio-availability studies.
II. Write notes on: (10 x 6 60)
1. Cytochrome p-450 enzyme system.
2. General aspects of receptor pharmacology.
3. Histamine and H1 antagonists.
4. Angiotensin Converting Enzyme inhibitors.
5. Management of heavy metal poisoning.
6. Pro-kinetic agents.
7. Eicosanoides.
8. Synthesis and degradation of catecholamines.
9. Opioid peptides and receptors.
10. Pharmacology of lithium carbonate.