THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[LM 344] MAY 2018 Sub. Code: 2905
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II PHARMACEUTICAL CHEMISTRY
PAPER II ADVANCED ORGANIC CHEMISTRY
Q.P. Code: 262905
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Explain in detail about the formation, structure, stability and reactions
involving Carbenes.
Outline each two synthetic methods for obtaining drug molecules having five
membered and six membered heterocyclic ring system.
2. Discuss on Nanochemistry with special reference to its application in drug
discovery.
Write a detailed note on aliphatic nucleophilic substitution.
II. Write notes on: (10 x 6 60)
1. Chemical bonding.
2. Mechanism and applications of Oppenauer oxidation.
3. Mechanism of Walden inversion.
4. Orbital symmetry rules and its applications.
5. Techniques for preparing chiral drugs.
6. Theory of photochemical reactions.
7. Mechanism and applications of Ozonolysis.
8. Elimination reactions.
9. Synthesis of Phenothiazines and Purines.
10. Neighbouring group assistance in Free radical reactions.