Advertisement No. 10/2015

Applications are invited from qualified, creative, self-motivated individuals for several positions in The Centre for Chemical Biology and Therapeutics (CCBT). The successful candidate will participate in a multidisciplinary research program in a new initiative for chemical biology and therapeutics research. The program is coordinated by Professor Ashok Venkitaraman (University of Cambridge, UK, and inStem).

The Centre for Chemical Biology and Therapeutics (CCBT) is an inter-institutional collaboration funded by the Department of Biotechnology, Government of India, the Institute for Stem Cell Biology and Regenerative Medicine (inStem) and the University of Cambridge (https://www.instem.res.in/research/center-for-chemical-biology-and-therapeutics). It is an integrated multidisciplinary research centre designed to pioneer new approaches to create small-molecule tools that target intracellular signaling pathways for chemical biology and molecular therapeutics, and use them to conduct hypothesis-generating and hypothesis-driven translational research on systems of biomedical importance. Its overall vision will be to foster innovative therapeutic interventions for important human diseases. It is located on the NCBS campus [www.ncbs.res.in] in north Bangalore, a premier site for biomedical research equipped with the latest instrumentation and facilities, with a flourishing community of academic and industrial researchers. The CCBT operates through the uniquely integrated effort of multidisciplinary project teams using common technological platforms, and not as a collection of independent PI-led labs that is usual in academia.

The prescribed qualification/experience for Associates it is Masters/Bachelors degree with 1-3 years experience of Academic or Industrial work experience.

Age will not be bar for candidates with exceptional experience in the specific field.

Salary and benefits will be attractive and will be commensurate with qualification/experience and performance in the interview.

Appointments to these posts are made for one year and extended thereafter based on performance of the candidate during the course of the CCBT project.

Name of the post and qualification/experience for each one are indicated below

SENIOR SCIENTIST Cell Molecular Biologist/Assay Development

KNOWLEDGE, EXPERIENCE AND SKILLS:

• PhD in Molecular Biology/Cell Biology/Biochemistry or other relevant fields

• 2-4 yrs of postdoctoral/industry experience in cell-based assay development, immunocytochemistry/high-content imaging is a must

• Experience in basic biochemistry techniques like immunoprecipitations, pull down assays, Western blotting etc. is required

• Knowledge in basic Molecular biology techniques like transformations, cloning, site-directed mutagenesis and stable cell line generation would be desirable

• Self-motivated candidates should have managed junior scientists with the capability to design, develop and troubleshoot experiments

• Excellent communication and presentation skills

• Must be detail oriented, well organized with ability to analyze and communicate data effectively

• Excellent teamwork required and to work in a fast-paced, multi-disciplinary environment

• meeting timelines

• Good understanding of cell signaling pathways, disease biology having therapeutic implications would be required

JOB DESCRIPTION

In this position you will support chemical biology efforts underpinning new lead discovery by providing cell biology expertise including, but not limited to the following;

• Develop, optimize and validate cell-based assay platforms for the hit to lead identification of small molecules in our drug discovery programs

• Collaborate with multidisciplinary project teams like high throughput screening, computational biology, medicinal chemistry and protein biology in the discovery and identification of small molecules

• Plan experiments, order reagents, set up assay platforms and deliver them in a timely fashion

• Regular data analysis, project updates, literature survey and presentations on the target

• Participate in project team meeting and contribute to the projects intellectually

DUTIES AND JOB FUNCTIONS

• Specific experience with cell biology and assay development applying luminescence, fluorescence, TR-FRET, FP, fluorescent immunocytochemistry, high content analysis, automated microscopy, label-free and other in vitro detection technologies

• Ability to work on the bench implementing state-of-the-art technologies for the different assay platforms

• Capability to perform basic biochemistry and molecular biology techniques

• Excellent in data analysis, interpretation and communication

• Must be detail oriented, well organized, and have strong communication skills

• Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment

• Managerial experience of junior scientists

ASSOCIATE RESEARCH SCIENTIST: Cell Molecular Biologist/Assay Development

KNOWLEDGE, EXPERIENCE AND SKILLS:

• Master's degree in the discipline of life sciences with 1-3 years of academic or industrial work experience

• Substantial experience in cell based assay development, immunocytochemistry, biochemistry (immunoprecipitations, Western blotting etc.) and molecular biology techniques (transformation cloning, stable cell line generation etc.) would be preferred

• Must be detail oriented, well organized with ability to analyze and communicate data effectively

• Excellent teamwork required and to work in a fast-paced, multi-disciplinary environment meeting timelines

JOB DESCRIPTION

In this position you will support chemical biology efforts underpinning new lead discovery by providing cell biology expertise including, but not limited to the following;

• Develop, optimize and validate cell-based assay platforms for the hit to lead identification of small molecules in our drug discovery programs

• Collaborate with multidisciplinary project teams like high throughput screening, computational biology, medicinal chemistry and protein biology in the discovery and identification of small molecules

• Plan experiments, order reagents and set up assay platforms and deliver them in a timely fashion

• Regular data analysis, project updates, literature survey and presentations on the target

• Participate in project team meeting and contribute to the projects intellectually

DUTIES AND JOB FUNCTIONS

• Understanding of cell biology, molecular biology and assay technologies

• Experience in using luminescence, fluorescence, TR-FRET, FP, fluorescent immunocytochemistry, high content analysis, automated microscopy, label-free and other in vitro detection technologies

• Computer skills with experience in data analysis

• Must be detail oriented, well organized, and have strong communication skills

• Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment

HOW TO APPLY: Interested candidates may send in the following information by email to jobs-ccbt@instem.res.in.

• Curriculum Vitae (CV)

• Publication list

• Contact details of three professional referees.

NO PAPER APPLICATIONS will be accepted.

Last date for receipt of Applications is 15 days from the date of advertisement.

inStem reserves the right to fill or not to fill the posts advertised.