M.Sc.(Semester Examination Oct/Nov-2017
Biotechnology
CLINICAL BIOINFORMATICS
Day Date: Thursday, 23-11-2017 Max. Marks: 70
Time: 10.30 AM to 01.00 PM
Instructions: Part-I, Questions-1 is compulsory.
Attempt any-4 question from part- II.
Figures to the right indicate full marks.
Answer to the Part- I and Part- II are to be written in same answer booklet
only.
Part I
Q.1 Rewrite the sentence after choosing the correct answer from the given
alternatives:
07
The technology has been available and can generate
about 100 million reads per run on a single sequencing machine.
California Standford
Illumina All of above
A wide variety of microarray analysis tools are available through
Bioconductor written in the programming language.
C Java
Perl R
FastQC next generation sequencing tool is tool on platform.
Illumina FASTQ
GNU Glib CASAVA
The first pathogen genome that of was sequenced by
traditional Sanger methods.
Hemophilic influenza Staphylococcus epidermidis
Staphylococcus aureus Neisseria meningitides
is the total number of metabolites present within an
organism, cell or tissue.
Proteome Metabolome
Genome Pharmacogenomics
is a joint scientific project between the European
Bioinformatics Institute and the Wellcome Trust Sanger institute.
NCBI Ensembl
Swiss Prot BioMart
International Statistical Classification of Diseases is developed by

Sanger WHO
ICHI ICF
Page 2 of 2
SLR-ME-97
Define the following: 07
Transcriptomics
Microarray
Pathology informatics
Medical coding
Metabolomics
HGP
Pharmacogenomics
Part II
Answer Any Four of the following:
Q.2 Write a detailed note on various platforms and applications of NGS. 14
Q.3 Define medial bioinformatics. Add a note on disease under its study. 14
Q.4 Explain the challenges and applications o Human Genome Project. 14
Q.5 Answer any two from the following: 14
Add a note on R scripting with its applications.
Write note host-pathogen interactions?
Explain the international classification of diseases.
Q.6 Write short notes on any two of following: 14
Genome mapping
Genetic diseases
Systems biology