M.Sc. (Semester II) (CBCS) Examination Mar/Apr-2018
Bioinformatics
ADVANCED BIOINFORMATICS
Time: 2½ Hours
Max. Marks: 70
Instructions: Section-1, Question 1 is compulsory. Attempt any four questions from Section-II. Figures to the right indicate full marks. Answer to the Section-I and Section-II are to be written in same answer Booklet only.
Section I
Q.1

Rewrite the sentence after choosing the correct answer from the given alternatives:
07
In S-W algorithm the trace back begins at the value found anywhere in the matrix.
Minimum
Zero
Maximum
None of these
KEGG stands for
Kyoto Encyclopedia of Genome
Kyoto Encyclopedia of Genes and Genomes
Kyoto Encyclopedia Graph
All of these
ORF stands for
Old Reader Field
Open Reading Flank
Open Reading frame
None of these
Each amino acid corresponds to a turn in an alpha helix.
1200
1000
850
None of these
In Dali-lite program graphical result is viewed by viewer.
Jet
Jlib
Jmol
All of these
Phylogenetic relationship can be shown by
Data retrieving tool
Data search tool
Dendogram
Genbank
is a tool for Computing, Evaluating and Manipulating Multiple Alignments of DNA, RNA, Protein Sequences and structures.
Phylogibb
Dotlet
SIBsim4
T-Coffee

Definition:
Coiled coils
Genomics
Phylip
Molecular Clock
Proteomics
Introns
EC
Page 2 of 2
SLR-UC-61
Section II
Answer any four of the following.
Q2
Explain the Needleman and Wuncsh algorithm for pair wise alignment and its implementation.
14
Q3
Explain molecular taxonomy and phylogeny in details and also add a detailed a note on maximum parsimony and maximum likelihood methods.
14
Q4
Give a detailed description on KEGG pathway database and add a note on its applications.
14
Q5
Answer any two of the following.
14
Explain SNP database in details.
Explain the Mega blast algorithm and add a note of BLAST2.
Give a description on the secondary structural elements.
Q6
Write short note any two of the following.
14
UPGMA
EXPASY Server
PAM Matrices