B.Sc. II (Semester III) (Biotechnology) (CBCS) Examination, 2018
fundamentals of immunology
Day and Date Thursday, 6-12-2018 Total Marks 70
Time 2.30 p.m. to 5.00 p.m.
Instructions All questions are compulsory.
Draw neat labeled diagram wherever necessary.
1. Choose the correct alternative and rewrite the sentences. 14
MHC genes in human are present on chromosome.
14 7
12 6
ii) Tritium is used in test.
Radioimmunoassay Immune-fluorescence
ELISA Complement fixation
iii) Administration of vaccine is called as
Artificial passive immunization
Artificial active immunization
Natural active immunization
Natural passive immunization
iv) antibody is called as reagin antibody.
IgG IgM IgA IgE
is primary lymphoid organ.
Spleen Bone marrow
Peyer's patch Lymphnode
vi) is example of incomplete antigen.
Forssmann Eye lens protein
Hapten Blood group
vii) Widal test is an example of type of reaction.
Agglutination Flocculation
Precipitation Complement fixation
viii) cells are called as null or third population cells
Tc Th Dendritic NK
ix) test is used in diagnosis of syphilis.
VDRL Widal
Tuberculin Montoux
The signal transduction from one cell to neighboring cell is called as
Autocrine Paracrine
Endocrine Synergism
xi) class of immunoglobulin is involved in secondary immune response.
IgG IgM IgA IgD
xii) mediator bind to hypothalamus and induce fever.
Prostaglandins Histamine
Leukotrienes Thromboxane
xiii) Antigenicity is enhanced by adding
Epitope Adjuvant
Hapten Antibody
xiv) Example of mucosa associated lymphoid tissue
Thymus Spleen
Payer's patch Lymphnode
2. Answer the following (any four). 8
Synergy and redundancy.
ii) Enlist secondary lymphoid organs.
iii) Enlist factors affecting innate immunity.
iv) Isoantigen and autoantigens.
Function of NK cells.

Write note on (any two). 6
Factors affecting antigenicity.
Th cells and Tc cells.
Structure and function of spleen.

3. Answer the following (any two). 8
Explain structure and function of MHC class I molecule.
ii) Explain mechanism of phagocytosis.
iii) Explain structure and function of antibody molecule.
Answer the following (any one). 6
Physical barriers of Innate Immunity.
ii) Write an essay on principle of antigen and antibody interaction.
4. Answer the following (any two). 10
Explain any two antigen and antibody reactions by precipitation.
ii) Explain properties of cytokines.
iii) Explain Radioimmunoassay.
Answer the following (any one). 4
Explain structure and function of cytokine receptors.
ii) Explain B cells.
5. Answer of the following (any two). 14
Explain structure and function of primary lymphoid organs.
ii) Explain ELISA.
iii) Programmed cell death.