M.Sc. (Semester III) (CBCS) Examination Nov/Dec-2018
Bioinformatics
ADVANCED BIOPHYSICAL TECHNIQUES
Time: 2½ Hours Max. Marks: 70
Instructions: All questions are compulsory.
Figures to the right indicate full marks.
Q.1 Multiple choice Questions:- 14
of the intermolecular bonding interactions below are
possible for a secondary amide.
Hydrogen bonding only
Vander Waals Interactions Only
Ionic Bonding Only
Both hydrogen Bonding and ionic Bonding
of the following statements is true regarding a secondary amide.
It can only participate in hydrogen bonding as a hydrogen bond donor
It can only participate in hydrogen bonding as a hydrogen bond acceptor
It can participate in hydrogen bonding both as a hydrogen bond donor
and a hydrogen bond acceptor
It cannot participate in hydrogen bonding at all
of the following major aims in drug design is not related to the
pharmacodynamics of a drug.
The reduction of side effects
The maximization of activity
The reduction of toxicity
The maximization of oral bioavailability
of the following is a noble gas configuration.
1s2 2s2 1s2 2s22p6
1s2 2s22p63s2 1s2 2s22p63s23p63d10
There are types of molecular orbitals.
1 2
3 4
of the following is non-polar bond.
C-H C=O
N-H C-C
of the following bonds is most strongly polarized.
C-H C=O
N-H C-N
of the following molecules will not display an infrared spectrum.
CO2 N2
Benzene HCCH
One of the following nuclei has a magnetic moment (so that an
NMR experiment can be performed).
12C 16O
14N 32S
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10) In a proton NMR experiment with a frequency of 60 MHz, the magnetic
field B require for resonance is 1.4 T. calculate the magnetic field required
for resonance of the proton in a spectrometer with a frequency of 500 MHz.
2.8 T 11.7 T
0.7 T 14.0 T
11) In a time-of-flight mass spectrometer, the velocity of an accelerated ion is
related to its mass by of the following.
Proportion to m (its Mass)
Inversely proportional to its mass
Proportional to the square root of its mass
Inversely proportional to the square root of its mass
12) For the molecule CBr4, the number of peaks which comprise the cluster for
the molecular ion will be of the following.
1 4
5 3
13) A device which converts electrical energy in the form of a current into
optical energy is called as
Optical source Optical coupler
Optical isolator Circulator
14) Identify of the following pairs of molecules exhibits both a pure
rotational spectrum and a rotational Raman spectrum.
O2 and H2O CO2 and N2O
CO and CH4 NO and DCCH
Q.2. Answer any four of the following. 08
Valency
Hydrogen bond
Spectroscopy
Circular Dichroism
Cuvette
Write notes on. (Any Two) 06
X-radiation
Atomic Force microscopy
Electron density
Q.3. Answer the following. (Any Two) 08
Non-bonding interactions
Instrumentation of UV-Visible spectrophotometer
Difference between of CD and ORD.
Answer the following:- (Any One) 06
Write the principle of MALDI TOF.
Brief out Electromagnetic spectrum.
Q.4. Answer the following. (Any Two) 10
Explain the X-Ray Diffraction.
Explain principle of Scanning Electron Microscopy.
Add a note on Fluorescent microscopy.
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Answer the following:- (Any One) 04
Define covalent bond. Add a note on its types.
Write the working of FTIR.
Q.5. Answer the following (Any Two) 14
Briefly explain the principles and theory and instrumentation of NMR
Discuss the types of lasers with examples.
Application of X-rays in medicine