M.Sc. (Semester II) (CBCS) Examination Nov/Dec-2018
Bioinformatics
ADVANCED BIOINFORMATICS
Time: 2½ Hours Max. Marks: 70
Instructions: Part-1, Question 1 is compulsory
Attempt any four questions from Part-II
Figures to the right indicate full marks.
Answer to the Part-I and Part-II are to be written in same answer Booklet
only.
Section I
Q.1 Rewrite the sentence after choosing the correct answer from the
given alternatives:
07
is clustering method for the creation of Phylogenetic
trees created by Naruya Saitou and Nei in 1987.
MP ML
UPGMA N-J
The based method makes predictions based on significant
matches of the query sequence with sequences of known genes.
Ab initio Homology
HMM Neural network
is the replacement of a single amino acid in the primary
structure of a protein with another single amino acid, which is
accepted by the processes of natural selection.
PAM BLOSUM
Pairwise Multiple
plant database resource for integrative and
comparative plant genome research.
Pathogen PHI BASE
MIPS All of these
ORF stands for
Open reading frequency Open random frame
Open reading Frame None of these
is a web-based program that combines neural network
with multiple sequence alignment.
PSI PRED PHD
Protparam pfam
is a technique used by molecular biologists to produce
a snapshot of the messenger RNA population.
OMIM SNP
SIFT SAGE
Page 2 of 2
SLR-VC-52
Definitions 07
Sequence identity
Chip
Coil
Suffix Tree
Protparam
Rooted Tree
Profile
Section II
Answer any four of the following.
Q2 Explain identification of SNP in disease and SNP database with its
applications.
14
Q3 Explain in detail UPGMA, NJ, Maximum Parsimony phylogenetic method in
details.
14
Q4 Explain the gene prediction in prokaryotic and eukaryotic in details and add a
note on plant and animal database.
14
Q5 Answer any two of the following. 14
Write a note on ExPasy server.
Explain KEGG database in detail.
Write a note on DNA microarray and its applications.
Q6 Write short notes on. (Any two) 14
Smith-waterman algorithm
OMIM database
PSI and Mega Blast